Coronavirus Infection COVID-19 and Pregnancy.

The novel coronavirus infection SARS-CoV-2, which broke out in China in December 2019, has rapidly spread around the world. On March 11, 2020, the World Health Organization (WHO) assigned this infection pandemic status. Pregnant women and puerperae occupy a special place in the structure of the incidence of COVID-19. For more than a year and a half, the Lapino Clinical Hospital of the Mother and Child Group of Companies has accumulated significant experience in managing patients with COVID-19, including pregnant women and puerperae. This article presents the features of the course of the new coronavirus infection in pregnant women and puerperae during various periods of the pandemic, the experience of managing pregnancy and childbirth in the above group of patients, and methods of treatment.

Experience of veno-venous extracorporeal membrane oxygenation in a pregnant woman with severe acute respiratory distress syndrome caused by the SARS-CoV-2 virus

Pregnant women occupy a special place in the incidence structure of the new coronavirus infection COVID -19. Taking into account the likelihood of a more severe course of acute respiratory syndrome (ARDS) in this group, it is worth remembering the possibility of timely use of veno-venous extracorporeal membrane oxygenation (IV ECMO) in order to correct life-threatening hypoxia. At the Lapino Clinical Hospital, a cesarean section was successfully performed in a 37-year-old female patient at 20–21 weeks of gestation against the background of IV ECMO with further decannulation and discharge from the hospital. © 2021 Sklifosovsky Research Institute for Emergency Medicine. All rights reserved.

COVID-19 and iron deficiency anemia: Relationships of pathogenesis and therapy

During pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflammation marker concentrations (C-reactive protein, interleukin-1β, interleukin-6, interferon-γ, ferritin, erythrocyte sedimentation rate etc.). Cytokine storm increases a risk of pregnancy loss and contribute to formation of multiple organ dysfunction syndrome in pregnant women and fetus. In particular, erythrocyte degradation due to acute inflammation leads to hypoxia and uncontrolled inter-tissue iron redistribution. As a result, conditions are created simultaneously for developing pulmonary hemosiderosis and hemosiderosis of other tissues in pregnant woman and fetus, as well as for augmenting iron loss from the body, which exacerbates iron deficiency anemia (IDA). It is important to emphasize that a surge of ferritin level distinctive for severe COVID-19, does not indicate iron overload. Therefore, recommendations to cancel IDA correction and even to use iron chelators in COVID-19 may increase hypoxia and harm the health of pregnant women.